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KMID : 0043320060290100884
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Archives of Pharmacal Research
2006 Volume.29 No. 10 p.884 ~ p.889
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Mutant Presenilin 2 Causes Abnormality in the Brain Lipid Profile in the Development of Alzheimer’s Disease
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Nguyen Hong Nga
Son Dong-Joo
Lee Jae-Woong
Hwang Dae-Youn
Kim Young-Kyu
Cho Jung-Sik
Lee Ung-Soo
Yoo Hwan-Soo
Moon Dong-Cheul
Oh Ki-Wan
Hong Jin-Tae
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Abstract
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Mutation in the presenilin 2 (PS2mt) is known to be one of factors involved in the development of Alzheimer’s disease (AD). It was recently revealed that an abnormality of lipid metabolism is a phenomenon occurring in AD. Therefore, the aim of this study was to investigate the potential relationship between the mutation of PS2 and alterations of the lipid profile within the brain. The results showed there increases in the levels of cholesterol, low density lipoprotein and triglyceride, but a decrease in the level of high density lipoprotein in brain tissues expressing mutant PS2. These findings indicated that PS2mt is involved in the abnormalities of the lipid profile, which could cause or result in the development of AD.
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KEYWORD
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Transgenic mice, Presenilin 2, Alzheimer’s disease, Cholesterol, Triglyceride, HDL cholesterol, LDL cholesterol
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